Question: What Is The Difference Between Biotransformation And Metabolism?

What is a biotransformation system?

Biotransformation is the process by which a substance changes from one chemical to another (transformed) by a chemical reaction within the body.

Metabolism or metabolic transformations are terms frequently used for the biotransformation process..

What are the phases of biotransformation?

Biotransformation Reaction Phases They are usually classified as Phase I and Phase II reactions. Phase I reactions are generally reactions which modify the chemical by adding a functional structure.

Does a fast metabolism affect medication?

Drug and Food Interactions. These can either increase or decrease CYP450’s ability to break down drugs. When they increase the enzyme’s metabolic function, the drug’s therapeutic effects may be decreased. When they decrease the enzyme’s metabolic function, the drug’s benefits may be compromised by intolerability.

What is metabolism in toxicology?

Drug metabolism is the process by which the body breaks down and converts medication into active chemical substances. Toxicology is a branch of Medical Science that deals with the effects of chemical compound used in the diagnosis, treatment, or prevention of disease or other abnormal condition on the body.

What is involved in Phases I and II of biotransformation?

Biotransformation involves two stages: phase I mainly involving P-450 (CYP) family and phase II catalyzed by conjugation enzymes like glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and N-acetyltransferase (NAT).

How do I know what metabolic type I am?

A metabolic test is performed in order to estimate your BMR or basal metabolic rate. Rather basic and simple, the test commonly involves having the patient breathe into a tube for up to 10 minutes. This is supposed to help calculate the amount of oxygen that was inhaled to the amount of carbon dioxide that was exhaled.

What is the main purpose of metabolism?

The three main purposes of metabolism are: the conversion of food to energy to run cellular processes; the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes.

What is the difference between Phase 1 and Phase 2 metabolism?

Phase I reactions of drug metabolism involve oxidation, reduction, or hydrolysis of the parent drug, resulting in its conversion to a more polar molecule. Phase II reactions involve conjugation by coupling the drug or its metabolites to another molecule, such as glucuronidation, acylation, sulfate, or glicine.

Is it good to have a high metabolism?

If your metabolism is “high” (or fast), you will burn more calories at rest and during activity. A high metabolism means you’ll need to take in more calories to maintain your weight. That’s one reason why some people can eat more than others without gaining weight.

What is biotransformation and where in the body does it occur?

Primary Biotransformation Site: The Liver Microsomal enzymes are associated with most Phase I reactions. … Cytosolic enzymes are non-membrane-bound and occur free within the cytoplasm . They are generally associated with Phase II reactions, although some oxidation and reduction enzymes are contained in the cytosol .

What are the 3 female body types?

Most people are unique combinations of the three body types: ectomorph, mesomorph, and endomorph. Ectomorphs are long and lean, with little body fat, and little muscle.

How do Endomorphs lose weight?

Since you don’t burn calories as fast as ectomorphs and mesomorphs, excess calories are more likely to convert to fat. Some believe you’re also less tolerable to carbohydrates, so the best diet for your body type may be one with a higher fat and protein intake and a lower carbohydrate intake, such as the paleo diet.

What are the 3 metabolic types?

There are three basic metabolism types: ectomorph, mesomorph, and endomorph – definitely words you probably don’t use in your normal, day-to-day conversations.

What is phase 1 metabolism?

Phase 1 metabolism involves chemical reactions such as oxidation (most common), reduction and hydrolysis. There are three possible results of phase 1 metabolism. The drug becomes completely inactive. … One or more of the metabolites are pharmacologically active, but less so than the original drug.

Where does Phase 1 and 2 metabolism occur?

The liver is the primary site for metabolism. Liver contains the necessary enzymes for metabolism of drugs and other xenobiotics. These enzymes induce two metabolism pathways: Phase I (functionalization reactions) and Phase II (biosynthetic reactions) metabolism.